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Phlebovirus diversity in ticks from livestock in arid ecologies in Kenya

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dc.contributor.author Ogola, Edwin O
dc.contributor.author Kopp, Anne
dc.contributor.author Bastos, Armanda D.S
dc.contributor.author Slothouwer, Inga
dc.contributor.author Omoga, Dorcus C.A.
dc.contributor.author Osalla, Josephine
dc.contributor.author Sang, Rosemary
dc.contributor.author Torto, Baldwyn
dc.contributor.author Junglen, Sandra
dc.contributor.author Tchouassi, David P
dc.date.accessioned 2023-01-21T15:28:36Z
dc.date.available 2023-01-21T15:28:36Z
dc.date.issued 2022
dc.identifier.uri http://hdl.handle.net/20.500.12562/1787
dc.description publication en_US
dc.description.abstract Phleboviruses are emerging pathogens of public health importance. However, their association with ticks is poorly described, particularly in Africa. Here, adult ticks infesting cattle, goats and sheep were collected in two dryland pastoralist ecosystems of Kenya (Baringo and Kajiado counties) and were screened for infection with phleboviruses. Ticks mainly belonged to the species Rhipicephalus appendiculatus, Hyalomma impeltatum, and Hyalomma rufipes. A fragment of the RNA-dependent RNA polymerase (RdRp) gene was identified in thirty of 671 tick pools, of which twenty-nine were from livestock sampled in Baringo county. Phylogenetic analyses revealed that twenty-five sequences were falling in three clades within the group of tick-associated phleboviruses. The sequences of the three clades showed nucleotide distances 8%, 19% and 22%, respectively, to previously known viruses suggesting that these sequence fragments may belong to three distinct viruses. Viruses of the group of tick-associated phleboviruses have been found in several countries and continents but so far have not been associated with disease in humans or animals. In addition, five sequences were found to group with the sandfly-associated phleboviruses Bogoria virus, Perkerra virus and Ntepes virus recently detected in the same region. Further studies are needed to investigate the transmission and maintenance cycles of these viruses, as well as to assess their potential to infect vertebrates. en_US
dc.description.sponsorship Deutsche Forschungsgemeinschaft (JU 2857/9–1 to S.J.) and the German Center for Infection Research (DZIF), Germany (TTU 01.801). Edwin O. Ogola was supported by a German Academic Exchange Service (DAAD) through the icipe ARPPIS-DAAD scholarship and a UP postgraduate bursary. David P. Tchouassi is supported by a Wellcome Trust International Intermediate Fellowship (222,005/Z/20/Z) and from the Norad-funded project Combatting Arthropod Pests for better Health, Food and Climate Resilience (CAP-Africa; project number RAF-3058 KEN-18/0005). We gratefully acknowledge the financial support for this research by the following organizations and agencies: Swedish International Development Cooperation Agency (Sida), Swiss Agency for Development and Cooperation (SDC), Australian Centre for International Agricultural Research (ACIAR), Federal Democratic Republic of Ethiopia and the Government of the Republic of Kenya. en_US
dc.publisher Ticks and Tick-borne Diseases en_US
dc.rights Attribution-NonCommercial-ShareAlike 3.0 United States *
dc.rights.uri http://creativecommons.org/licenses/by-nc-sa/3.0/us/ *
dc.subject Arbovirus en_US
dc.subject Phleboviruses en_US
dc.subject Tick en_US
dc.subject Livestock en_US
dc.subject Dryland ecosystem en_US
dc.subject Kenya en_US
dc.title Phlebovirus diversity in ticks from livestock in arid ecologies in Kenya en_US
dc.type Article en_US


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