Biochemical and Genetic Studies of Antibody (IgM) Producing Cells

Abstract

We have chosen the urine innurioglobulin M (IgM) as system to study glycoprotein biosynthesis and carbohydrate processing. Secreted IgM heavy chain (m) has five glycoasylation sites which location and structures have been determined. chain variable region (VH) ia involved in antigen binding, while the constant region (CH) is responsible £or the effector functions in which the carbohydrate plays an important role. ........(continue from the attached pdf)